Case Studies
Filter by recent cases, tags, and specialty, and cross-link to Forum and Patient Questions.
Case list
Case #2
Test2
40s, Male
Patient Characteristics
Summary
A male in their 40s presented with new-onset hypertension, hyperglycemia, weight gain, fatigue, and right flank pain, leading to the discovery of a large right adrenal mass. Biopsy confirmed high-grade adrenocortical carcinoma (ACC) with TP53 and CTNNB1 mutations, and MSI-H/dMMR, staged as metastatic (cT3N1M1) with liver and suspected lung involvement. Initial systemic therapy with EDP plus mitotane resulted in stable disease, followed by progression in the liver, which was subsequently managed with local SBRT. The patient then received pembrolizumab based on MSI-H/dMMR status, achieving a partial response with improved hormonal symptoms, and continues on this therapy.
Full notes
